Lindera glauca stem extract has antioxidant and protective effects against oxidative stress

Researchers from Konkuk University in South Korea investigated the antioxidant and protective effects of Lindera glauca stem (LGS) extracts against oxidative stress. The results of their study were published in the Journal of Medicinal Food.

• The researchers compared the antioxidant properties of the water (LGSW) and ethanol (LGSE) extracts of L. glauca by determining the compounds responsible for their antioxidant activities.
• They also assessed the antioxidant properties of both extracts using 2,2?-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assays.
• To estimate lipid peroxidation, they used the ferric thiocyanate (FTC) and thiobarbituric acid (TBA) method.
• The researchers reported that both LGSW and LGSE strongly inhibited lipid peroxidation.
• LGSE increased the viability of Chang cells (liver cell line) and decreased intracellular reactive oxygen species (ROS) levels after treatment with tert-butyl hydroperoxide to induce oxidative stress.
• LGSE also increased the activities of antioxidant enzymes, such as catalase, glutathione S-transferase, glutathione peroxidase and superoxide dismutase, by increasing their expression in a zebrafish model of oxidative stress.

Based on these results, the researchers concluded that the ethanol extract of L. glauca can protect cells against oxidative stress, thanks to its polyphenol and flavanoid content.

Journal Reference:

Kim YS, Kim EK, Dong X, Park JS, Shin WB, Kim SJ, Go EA, Park PJ, Lim BO. LINDERA GLAUCA (SIEBOLD ET ZUCC.) BLUME STEM EXTRACTS PROTECT AGAINST TERT-BUTYL HYDROPEROXIDE-INDUCED OXIDATIVE STRESS. Journal of Medicinal Food. 14 May 2019;22(5):508–520. DOI: 10.1089/jmf.2018.4289